Sixteen (15.5 %) were familial cases, 16.5 % had focal cortical dysplasia (FCD). We included 103 SHE patients (M/F:61/42) who underwent NGS. The identified heterozygous variants were classified according to the American College of Medical Genetics and Genomics guidelines. We selected familial and isolated cases diagnosed with clinical/confirmed SHE who underwent genetic analysis by comparable next generation sequencing (NGS) techniques (WES/ multigene epilepsy panel). We systematically investigated a large cohort of SHE patients to estimate the frequency of pathogenic variants in the main genes thus far implicated in this epilepsy syndrome. This approximate estimate comes from different case-series, each focused on the screening of a single gene. Genetics of Sleep-related Hypermotor Epilepsy (SHE) includes mutations in several genes that cumulatively account for 30 % of families.
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Also, be sure to right click the exe and always select “Run as administrator” if you’re having problems saving the game. Look for a ‘HOW TO RUN GAME!!.txt’ file for more help. You need these programs for the game to run. If you get any missing dll errors, make sure to look for a _Redist or _CommonRedist folder and install directx, vcredist and all other programs in that folder. NOTICE: This game is already pre-installed for you, meaning you don’t have to install it. Don't forget to run the game as administrator. Have fun and play! Make sure to run the game as administrator and if you get any missing dll errors, look for a Redist or _CommonRedist folder and install all the programs in the folder.ĭX-Ball 2: 20th Anniversary Edition Free DownloadĬlick the download button below to start DX-Ball 2: 20th Anniversary Edition Free Download with direct link.Double click inside the DX-Ball 2: 20th Anniversary Edition folder and run the exe application.zip file and click on “Extract to DX-Ball 2: 20th Anniversary Edition” (To do this you must have 7-Zip, which you can get here). Once DX-Ball 2: 20th Anniversary Edition is done downloading, right click the.Now let the download begin and wait for it to finish. Wait 5 seconds and click on the blue ‘download now’ button.Click the Download button below and you should be redirected to UploadHaven.How to Download & Install DX-Ball 2: 20th Anniversary Edition Play in “Classic” mode with only the original features and graphics.Collect in-game charms for extra points and achievements.Includes editing tools and full workshop support for creating and sharing custom boardsets with the community.Compete for the best score with new online leaderboards.Saved games allow you to save your progress and continue later. Move the ball from a distance with the gravity push/pull paddle.Shoot the ball extra fast to instantly break multi-hit bricks with the new punch paddle!.20 classic power-ups plus the all-new gravity-ball, lightning and more!.Switch between new high-res board textures or the original 90’s graphics at any time.New dynamic animated boards change as you play!.150 Boards from the original Board Pack 1 (aka Full Version) plus the all-new anniversary boardset and widescreen variants.Seumas McNally’s fan-favourite DX-Ball 2 has been re-mastered for modern PCs while retaining all of the classic brick-breaking action and unique graphic style of the late 90’s original. After more than 5 million downloads, the king of break-out games is back in a special 20th Anniversary Edition. If you have an Spectra 9 Plus don’t forget to give us your feedback! Contents If you are exclusively pumping or needing to rely on a pump to establish supply, we do always recommend you use a hospital grade breast pump – i.e.Is noisier than the S2 and Dew models (but not as noisy as other pumps – we do try our best to keep the noise down! Please check out youtube for some pump comparisons so you can get a feel for how much quieter Spectra pumps are than other brands!).Doesn’t provide as much flexibility over the pump program as the S2 (but still more than other pumps).Slow-flow teats are suitable for newborn feeding.As always with Spectra breast pumps, the Spectra 9 Plus has high performance vacuum with maximum suction of 300mmHg.Milk particles in the pump motor can lead to the growth of mould and is a potential source of virus transmission. Closed system – like all Spectra breast pumps, the Spectra 9 Plus has a closed system, which means that there is no way for milk to get into the pump motor.The Spectra 9 Plus is our most portable pump – lightweight and slimline, it will slip easily into your handbag. There’s a battery indicator so you know how much charge you have left on the battery AND there’s a timer so you can keep track of how long you’ve been expressing. LCD display so you can easily see where you’re at with vacuum and cycle settings.Use your Spectra 9 Plus while plugged into mains, or just use it wherever you like from its inbuilt rechargeable battery. Inbuilt rechargeable battery – yes, we know you love this feature.As you increase the suction, the speed will slow down. Easy adjustment of suction strength and cycle speed together – touch button controls allow you to adjust suction strength and cycle speed with one touch.This will get you expressing faster and help your body get on board with the job of expressing milk. Letdown mode – switch with a touch to the letdown mode, which is a light, quick mode designed to speed the start of milkflow, just the way a baby does.Just attach a milk collection kit to both nozzles if you will be double pumping, or if you only want to single pump, you can just close off the second nozzle. The Spectra 9 Plus has a nozzle for each milk collection kit, making it easy to swap from single to double pumping.Double pumping also ramps up levels of prolactin (the milk producing hormone) in your blood, so is better for supporting milk supply. The Spectra 9 Plus comes with a complete double kit so you can double pump – pumping both breasts at once saves so much time, which as a busy mum trying to find time to express, you will really appreciate.Read it through: What features does the Spectra 9 Plus have? Finally, the Spectra 9 has been re-released as the upgraded Spectra 9 Plus, which has all the features you loved about the Spectra 9 but with some very important extras to make your life easier. You can check out Mini Metro for yourself and play a game on the London map in the demo. I wasn’t just hypnotized by the rhythmic movement of trains from station to station, I was completely absorbed in making them perfect." - IGN Demo "Mini Metro’s clean, stylish interface encourages me over and over again to make the trains run on time, and there’s a deeper amount of strategy to growing a sprawling metro system than meets the eye. Buy There's a lot more in the full game: procedural audio by Disasterpeace, infinite-play zen mode, the unlockable extreme mode, leaderboards, multiple maps and themes based on real-world cities, and more cool stuff. If you love Mini Metro, check out the highway-planning follow up Mini Motorways! You can find us on all the usual social media haunts like Facebook and Twitter.
How do you make cobalt sulfate?Ĭobalt sulfate can be prepared by reacting cobalt metal, or cobalt oxide/hydroxide with aqueous sulfuric acid. For these purposes, treating cobalt oxide with sulfuric acid produces the cobalt sulfate, a method of manufacturing verified in Hawley’s Condensed Chemical Dictionary 16th Edition. What is cobalt sulfate used for?Ĭobalt sulfate is used in electroplating baths, storage batteries, sympathetic inks, and as an additive to soils and animal feeds. Cobalt Hydroxide is generally immediately available in most volumes. Is cobalt a hydroxide?Ībout Cobalt Hydroxide Cobalt Hydroxide is a highly water insoluble crystalline Cobalt source for uses compatible with higher (basic) pH environments. The complementary color, viz., blue is reflected.Ĭopper sulfate | CuSO4 – PubChem. Hence, the d-d transition takes place absorbing red wavelength. In the presence of these ligands, d-orbital are no longer degenerate in energy. In hydrated copper sulfate, four water molecules are present as ligands. By heating copper sulphide ores to produce copper oxide which is then treated with sulphuric acid to form copper sulphate. How do you type CuSO4?īy heating copper scrap with sulphur to produce copper sulphide which is then oxidised to form copper sulphate. Sugar is ionic because it melts and is soluble in water. Baking soda is ionic because it is made up of sodium, a metal, and carbon, a nonmetal. Corn starch is covalent because it doesn’t dissolve in water, and is not a crystal. Sand is a covalent compound because it is made of silicon and oxygen which are nonmetals. Like carbon dioxide (CO2), its molecular structure is linear but unlike CO2 it is flammable. Carbonyl sulfide (COS) is a colorless gas with a sulfur-like odor. A firm could be in the seed stage for a few years, investing in seed-stage companies, but later, they might raise a larger fund to invest in later-stage companies. Over time, venture firms may invest in startups outside their typical stage range. important Keep in mind that none of these terms are standardized in any legal or universally recognized way. The types of VC firms are inextricably linked to the terminology of rounds. Many VC firms focus on particular stages, and a few focus on many stages. Venture capital firms and funds are semi-formally divided into stages of investment that reflect the maturity of the businesses they invest in. Hunter Walk and Satya Patel, Partners, Homebrew * Stage of Investment *Ī new VC fund is kind of like a startup, just one that writes checks instead of code. * Traditional examples of institutional investors include investment banks, endowments, hedge funds, and insurance companies. For example, an institutional investor may become a limited partner in a venture capital firm. Both make investments from pooled resources, but institutional investors typically act as intermediaries, rather than investing directly in companies. controversy Venture capital firms and institutional investors also are not technically the same thing, although many refer to venture capital firms as institutional investors. In a post on the Homebrew blog, Hunter and Satya announce that they’ve raised $50M for “Homebrew Fund II,” the second venture fund raised and managed by Homebrew. For example, Hunter Walk and Satya Patel run Homebrew, their venture firm. A venture firm is the perpetual legal entity under which many individual venture funds can be raised and closed over time. confusion Venture capital firms and venture capital funds are not the same thing. It is helpful to understand venture firms as institutional investors to differentiate them from other kinds of startup investors, such as angels, and when contrasting institutional venture rounds from angel rounds. Venture capital funds are typically structured as partnerships. Definition A venture capital fund (or venture fund) is a legal entity, created by-but separate from-a VC firm, that pools money from outside investors and directs investments to companies seeking capital. Scores of them lend their vast experience to mentor startups and college-age students to set them on their own paths to success.Definition A venture capital firm (VC firm or venture firm) is a collection of legal entities formed for the purpose of generating substantial returns for its investors by investing in high-risk companies that have yet to prove that their business models work and are sustainable in the marketplace. What may help Sarasota-Manatee stay at that top ranking is the prevalence of successful business executives, entrepreneurs and investors who have chosen to retire here. The ratings scored high population growth rates, education attainment, young adult affluence and the business tax environment. According to, they topped the list in 2017 as the best city in Florida to start their own business ventures. The outlook is also promising for young entrepreneurs, especially in the Sarasota-Manatee region. Perhaps more surprising to most people is that according to a 2017 Statista report, Florida ranks 7th in Venture Capital investing, behind the usual suspects: California, New York, Massachusetts, Illinois, Texas and Washington. 5000 list of fastest growing private companies are located in Florida. Inc.com reported that 340 of its 2018 Inc. Other reports cite the growing rise of angel funds, incubators, top universities, low cost of living and, of course, the weather. The ranking is based on small business-related taxes, regulatory environment and government spending. According to a Small Business & Entrepreneurship Council report, Florida is the fifth best state to start a business. While Florida is known for being a top tourist and retiree destination, it comes as a surprise to most people that it is also an exceedingly entrepreneur-friendly state. They bring their unique experience and resources to the next generation of innovators. Florida attracts some of the wealthiest and most successful thought leaders in the US from all over the world with an interest in making an impact in retirement by investing and mentoring. Florida is the third largest state in the US boasting a diverse economic landscape in arts and entertainment, top universities, growing entrepreneurship, a thriving real estate market and a top tourist destination. Changing the basic assumptions of software often means that it ends up broken he therefore recommends against doing so. Too much misalignment can lead to a demand in transforming the existing context, but in Evans' experience, they often don’t transform so well. An important question to ask is how misaligned its core domain is, when compared to the current view of the core domain, and how much this is constraining the evolvement of the business. This often results in two teams having to work in the same bounded contexts with an increasing risk of ending up with a big ball of mud.Ī Mature productive context is producing value, but probably built on concepts in the core domain that are outdated. After reorganising the business around business accounts and personal accounts, there are now two other subdomains, but the bounded contexts stay the same, which means they are now misaligned with the new subdomains. These two subdomains in the banking domain are also bounded contexts. He uses an example of a bank structured around cash accounts and credit cards. In an ideal world they coincide, but in reality they are often misaligned. One confusion that Evans sometimes notices in teams is differentiating between bounded contexts and subdomains. In a recently published presentation, he describes different kinds of bounded contexts, including some that involve microservices.Įvans, a thought leader in DDD and author of the seminal book Domain-Driven Design, notes that the bounded context as a concept has drawn increasing interest from the community over the years, but is still an area where there is more to be done. None of the large software systems he has been involved in have been anywhere near that tidy. But a description of a system that looks so tidy is, for him, very suspicious. A canonical context has a refined model and an expressive ubiquitous language with unambiguous definitions. A bounded context is a defined part of software where particular terms, definitions and rules apply in a consistent way, Eric Evans explained in his keynote at DDD Europe earlier this year. The most notable alternative to the Magnum would be the Cadillac CTS wagon. Narrow the offerings down by a radius around your ZIP code, and pay attention to the deal rating on each listing to see how a vehicle compares with others in a similar area.Īre there any good alternatives to the Magnum? Our used vehicle listings can be helpful to find a good deal near you. Unless you're only in it for the aesthetic and find a super clean V6, you're better off springing for SRT-8, or even the R/T. It was the only model offered with the 6.1-liter V8, and while its performance is paltry by the standards of modern SRT models, it was the biggest, baddest Hemi rocket on the road in 2006. While there's often nuance involved in picking the best version of a car, this one's pretty straightforward: the SRT-8 is where it's at. No manual gearbox was offered as an option. The Magnum's Mercedes-Benz commonalities facilitated some convenient parts-sharing arrangements, notably including the 5-speed automatic that sat behind each of the Magnum's four available engines. The SRT-8, which arrived in 2006, cranked that up to 425 horsepower and 420 pound-feet with a 6.1-liter V8. The R/T debuted with 340 horsepower and 390 pound-feet of torque thanks to its then-fresh but now-ubiquitous 5.7-liter Hemi V8. The 3.5-liter upgrade made a far more respectable 250 horsepower and 250 pound-feet, but the real fun started one step higher. The 2.7-liter V6 made 190 horsepower and 190 pound-feet of torque when it debuted in 2005, which was pretty middling even then. Models produced for the 2005-2007 model years especially came with dreary cabins and a borderline-asthmatic base engine. We won't mince words: the Magnum, broadly, was not Chrysler at its best. What is the ideal example of the Dodge Magnum? The Magnum was an early pioneer of Dodge's LX-led performance revival and was one of the first cars to wear the SRT-8 badge. This is a wagon that happened to come with not one, but two potent American V8s. Cleaner ones far more difficult to find and it's only a matter of time before they'll be truly scarce. Sadly, due at least partially to Chrysler's cringeworthy build quality at the time, many of them are now adorning junkyards. But the Magnum's combination of looks and everyday-branded availability made it accessible to enthusiasts of virtually any budget. Nor was it the only domestic station wagon to make a splash with enthusiasts over the past two decades Cadillac's likewise-short-lived CTS wagon takes that nod and earns a pile of extra credit for being offered with a high-performance V variant with an available manual. The Magnum was not a performance car, first and foremost. Why is the Dodge Magnum a future classic? By virtue of its early demise, the Magnum saw only modest upgrades over the course of its run and never benefited from the comprehensive powertrain overhaul that elevated its surviving siblings. Despite their much-improved powertrains and top-notch infotainment systems, the Charger, Challenger and 300 are still very similar to the cars that debuted in 2004. Chrysler's ongoing LX models have evolved too, though not nearly as much as many of their contemporaries. The automotive landscape has changed quite a bit over the past two decades. The Magnum too, technically, but it was discontinued after its 4th model year, way back in 2008. Who knew the Dodge Charger, Dodge Challenger and Chrysler 300 would live long enough that we'd forget about their long-lost sibling? Early examples of the Charger and 300 have now reached smoking age (no more hiding burnouts under the bleachers). The exhaust note might as well have been a recording of some folks chanting "U-S-A!" at a backyard bar-b-q. The Magnum was big, brash and unapologetically present. If anybody knows how to do a modern wagon, it's the Germans, right?īut there was nothing characteristically German about what showed up in Dodge showrooms in 2005. It didn't hurt that then-DaimlerChrysler had decided to build its next round of large family sedans on a platform that was strategically seasoned with elements of the Mercedes-Benz W220 and W211 platforms, the former of which was already nearly a decade old. Ah, yes, the Dodge Magnum, arguably the forgotten LX and conceived back when Detroit bean counters still held out hope for the classic American station wagon. |